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Patients with a history of hypersensitivity to any of the ingredients of this drug.
Patients with severe liver disorder [The blood concentration would rise due to impaired metabolic function, which could strengthen the effects of the drug.]
Patients with myasthenia gravis [The muscle relaxing effects of the drug could exacerbate symptoms.]
Patients with acute narrow-angle glaucoma [The drug could increase intraocular pressure and exacerbate symptoms.]
Relative Contraindications: This drug is generally contraindicated in the following patients, but may be administered with caution if indispensable: Patients with acute pulmonary heart disease, pulmonary emphysema, bronchial asthma, and cerebrovascular disease whose respiratory function is highly compromised [Such patients are prone to carbon dioxide narcosis from respiratory depression.]
