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The administration of nephrotoxic and/or ototoxic medications should be avoided as much as possible during treatment with PARAPLATIN (see Precautions).
The combination with myelosuppressive substances leads to the potentiation of myelotoxicity.
Aminoglycosides: Caution should be exercised when administering PARAPLATIN with aminoglycosides due to cumulative nephrotoxicity and ototoxicity, particularly in patients with renal failure.
Loop diuretics: Caution should be exercised when administering PARAPLATIN with loop diuretics due to cumulative nephrotoxicity and ototoxicity, particularly in patients with renal failure.
Vaccines: There is increased risk of fatal systemic vaccine disease with the concomitant use of live vaccines. Live vaccines are not recommended in immunosuppressed patients (see Precautions).
