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To help avoid side effects and ensure proper use, talk to the healthcare professional before taking pms-DULOXETINE. Talk about any health conditions or problems the patient may have, including if the patient: Has or has a history of liver, kidney problems or heart problems, diabetes or seizures.
Has high blood pressure. pms-DULOXETINE may raise the blood pressure.
Has low sodium levels in the blood.
Is pregnant, is thinking about getting pregnant, or is breastfeeding.
Drinks alcohol or uses street drugs. Drinking a large amount of alcohol while taking pms- DULOXETINE may lead to serious liver problems and death.
Has an allergy to any medication.
Has a bleeding disorder that makes the patient more likely to bleed, or has low platelet levels (a type of blood cell).
Has problem urinating.
Has a rare hereditary disease that means the patient should not eat sugar. pms-DULOXETINE contains a type of sugar called sucrose. These diseases include: Fructose intolerance; Glucose-galactose malabsorption; Sucrose-isomaltase insufficiency.
Angle-closure Glaucoma: pms-DULOXETINE can cause an acute attack of glaucoma. Having the eyes examined before taking pms-DULOXETINE could help identify if the patient is at risk of having angle-closure glaucoma.
Seek immediate medical attention in case of: eye pain; changes in vision; swelling or redness in or around the eye.
Changes in behaviour and feelings, thoughts and actions about suicide: Treatment with these types of medications is most safe and effective when the healthcare professional and his/her patient have good communication about how the patient feels. It is helpful for the patient to tell a relative or close friend that he/she is depressed or has an anxiety disorder. They may tell if they think the patient is getting worse or if they are worried about changes in the patient's behaviour.
Some patients may feel worse instead of better when first starting drugs like pms-DULOXETINE or when changing the dose. The patient may feel more anxious, agitated, hostile, aggressive, impulsive, and feel like he/she is not himself/herself or become less inhibited. The patient may have thoughts of suicide, hurting himself/herself or other people. Thoughts and actions about suicide can occur especially if the patient has thoughts of hurting himself/herself in the past. These changes in behaviour and feelings can happen in patients of any age treated with pms-DULOXETINE at any age. Changes in suicidal thoughts and actions may be more likely if the patient is 18 to 24 years old. If this happens, seek immediate medical help. Do NOT stop taking pms-DULOXETINE without the doctor's advice.
Risk of breaking a bone: Tell the doctor if the patient: is elderly and had a recent bone fracture; or was told that he/she has osteoporosis or risk factors for osteoporosis.
Taking pms-DULOXETINE may increase the risk of breaking a bone. This is especially true when the patient first start taking pms-DULOXETINE and soon after stopping it. Take extra care to avoid falling, especially if the patient gets dizzy or has low blood pressure.
Serotonin syndrome/neuroleptic malignant syndrome (NMS): This is a rare side effect of the group of medications like pms-DULOXETINE. It is life-threatening and can lead to death. It can cause serious changes in how the brain, muscles, digestive system and nervous system work. The reaction is more likely if the patient takes pms-DULOXETINE with certain other medications. See Side Effects.
Driving and using machines: pms-DULOXETINE may make the patient feels dizzy or tired, especially just after starting it or after the dose is increased. Wait to see how the patient feels while taking pms-DULOXETINE before driving or using machines.
Use in Pregnancy: If the patient is or becomes pregnant while taking pms-DULOXETINE, talk to the healthcare professional about the risks and benefits of various treatment options. It is very important that the patient keeps taking pms-DULOXETINE until the healthcare professional tells when to stop.
When pregnant women took drugs in the same group of medications as pms-DULOXETINE, some newborn babies had complications at birth. This happened especially when the medication was taken in the last three months of pregnancy.
Some newborns: Required breathing support, tube feeding and a longer stay in the hospital; had difficulty feeding or breathing, seizures, tense or overly relaxed muscles and were jittery and cried constantly.
These symptoms normally go away over time. If the baby experiences any of these symptoms, contact the healthcare professional as soon as possible.
