Prevention of Rh(D) isoimmunisation in Rh(D) -ve women: Planned antepartum prophylaxis 300 mcg (1,500 IU) single dose by IV or IM at 28-30 wk of pregnancy. If beyond 30 wk, administer as soon as possible.
Antepartum prophylaxis following complications of pregnancy 300 mcg (1,500 IU) single dose by IV or IM, administered as soon as possible & w/in 72 hr. If >72 hr have elapsed, administer as soon as possible. Dose may be repeated at 6-12 wk intervals throughout the pregnancy, if necessary.
Postpartum prophylaxis 300 mcg (1,500 IU) single dose by IV or IM, administered to the mother as soon as possible w/in 72 hr of delivery of Rh +ve (D, D
weak, D
partial) baby, If >72 hr have elapsed, administer as soon as possible. When administered IV, min dose of 200 mcg may be sufficient provided that large feto-maternal haemorrhage can be excluded.
Large feto-maternal haemorrhage (>4 mL) 300 mcg (1,500 IU) single dose w/in 72 hr of complication + 10 mcg (50 IU) per 0.5 mL Rh(D) +ve fetal RBCs, or 10 mcg (50 IU) per 1 mL Rh(D) +ve fetal blood.
Incompatible transfusion of RBCs in Rh(D) -ve patient 20 mcg (100 IU) per 2 mL of transfused Rh(D) +ve blood or per 1 mL of Rh(D) +ve RBC conc. Max: 3,000 mcg (15,000 IU). Recommended to be administered IV.
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