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Concomitant use of Spravato with CNS depressants (e.g., benzodiazepines, opioids, alcohol) may increase sedation, which therefore should be closely monitored.
Blood pressure should be closely monitored when Spravato is used concomitantly with psychostimulants (e.g., amphetamines, methylphenidate, modafinil, armodafinil) or other medicinal products that may increase blood pressure (e.g., xanthine derivatives, ergometrine, thyroid hormones, vasopressin, or MAOIs, such as tranylcypromine, selegiline, phenelzine).
