View Tagrisso overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Swallow whole w/ water, or disperse in non-carbonated water & immediately swallow or administer through nasogastric tube.
Contraindications
Hypersensitivity. Concomitant use of St. John's wort.
Perform a validated test to determine EGFR mutation status. Discontinue permanently if patients develop ILD. Interrupt or discontinue immediately w/ signs & symptoms of SJS. Discontinue permanently if QTc interval prolongation develops in combination w/ torsade de pointes, polymorphic ventricular tachycardia, or signs/symptoms of serious arrhythmia. Cardiac monitoring in patients w/ cardiac risk factors; w/ conditions that can affect left ventricular ejection fraction; who develop relevant cardiac signs/symptoms. Refer promptly to ophthalmology specialist if presenting w/ signs & symptoms suggestive of keratitis. Caution in patients w/ severe or end-stage renal impairment; elderly >65 yr; body wt <50 kg. Not recommended in severe hepatic impairment. Fertility. Pregnancy & lactation.
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