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No data are available in humans with regard to overdose with latanoprost-timolol combination.
Symptoms: Symptoms of systemic timolol overdose are: bradycardia, hypotension, bronchospasm and cardiac arrest. Apart from ocular irritation and conjunctival hyperaemia, no other ocular or systemic side effects are known if latanoprost is overdosed.
Treatment: If symptoms of overdose occur the treatment should be symptomatic and supportive.
If accidentally ingested orally the following information may be useful: Studies have shown that timolol does not dialyse readily. Gastric lavage if needed. Latanoprost is extensively metabolised during the first pass through the liver. Intravenous infusion of 3 micrograms/kg in healthy volunteers induced no symptoms, but a dose of 5.5-10 micrograms/kg caused nausea, abdominal pain, dizziness, fatigue, hot flushes and sweating. These events were mild to moderate in severity and resolved without treatment, within 4 hours after terminating the infusion.
