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VYVANSE is contraindicated in: Patients with known hypersensitivity to amphetamine products or other ingredients of VYVANSE. Anaphylactic reactions, Stevens-Johnson syndrome, angioedema, and urticaria have been observed in post-marketing reports [see Post-marketing Experience under Adverse Reactions].
Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis [see Serotonin Syndrome under Precautions; Drugs Having Clinically Important Interactions with Amphetamines under Interactions].
