Zeffix怡干樂

Zeffix

lamivudine

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig
/
Agencia Lei Va Hong
Concise Prescribing Info
Contents
Lamivudine
Indications/Uses
Chronic hepatitis B in adults w/ compensated liver disease w/ evidence of active viral replication, persistent elevated serum ALT levels & active liver inflammation &/or fibrosis. (Initiation of lamivudine treatment should only be considered when the use of an alternative antiviral agent w/ a higher genetic barrier is not available or appropriate.) Chronic hepatitis B in adult w/ decompensated liver disease in combination w/ a 2nd agent w/o cross-resistance to lamivudine.
Dosage/Direction for Use
Administration
May be taken with or without food.
Contraindications
Special Precautions
Discontinue treatment when aminotransferase level elevates rapidly & progressive hepatomegaly or metabolic/lactic acidosis of unknown aetiology occur. Exacerbations of hepatitis on treatment & after treatment discontinuation. Exacerbations in patients w/ decompensated cirrhosis. Patients co-infected w/ HDV or HCV & HIV; those receiving concurrent immunosuppressive regimes, including cancer chemotherapy. Mitochondrial dysfunction. Monitor patient regularly (serum ALT, HBV DNA levels, HBeAg). Concomitant w/ emtricitabine, cladribine & other medicinal products containing lamivudine. May impair ability to drive & operate machinery. Pregnancy & lactation. Childn.
Adverse Reactions
Malaise & fatigue, resp tract infections, throat & tonsil discomfort, headache, abdominal discomfort & pain, nausea, vomiting, diarrhoea, ALT (during & post treatment) & CPK elevations, rash, pruritus, muscle disorders including myalgia & cramps.
Drug Interactions
Increased lamivudine exposure w/ trimethoprim/sulphamethoxazole. Concomitant use w/ cladribine & other cytidine analogues eg, emtricitabine. Potential risk of efficacy loss of cladribine. When possible, avoid chronic co-administration of Zeffix w/ medicinal products containing sorbitol, xylitol, mannitol, lactitol, maltitol.
MIMS Class
Antivirals
ATC Classification
J05AF05 - lamivudine ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Presentation/Packing
Form
Zeffix film-coated tab 100 mg
Packing/Price
28's
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