Allylestrenol

Oral
Threatened miscarriage
Adult: 5 mg tid for 5-7 days, treatment may be prolonged if necessary. Gradually reduce dosage if symptoms disappear.
Hepatic impairment: Contraindicated.

Oral
Recurrent miscarriage
Adult: 5-10 mg daily as soon as pregnancy is confirmed. Continue treatment for at least 1 month after the critical period.
Hepatic impairment: Contraindicated.

Oral
Premature labour
Adult: For threatened premature labour: Individualise dosage. Max: 40mg daily.
Hepatic impairment: Contraindicated.

May be taken with or without food. May be taken w/ meals if GI upset occurs.

Hypersensitivity. Hepatic impairment.

Patient with diabetes. Pregnancy.

Significant: Visual disturbances, proptosis or diplopia, vascular retinal ulcer; migraine. Gastrointestinal disorders: Nausea, vomiting.

Allylestrenol is a synthetic progestogen structurally related to progesterone. It exhibits trophoblastic, placentotrophic, and β₂-adrenergic activity with no androgenic action. Allylestrenol stimulates the hormonal effects of existing syncytiotrophoblast which are necessary for progesterone production. The pregnancy-maintaining effect is due to the stimulation of the placental function, and the stimulation of β₂-adrenergic receptors prevents uterine contractility.

Oestrogens & Progesterones & Related Synthetic Drugs

G03DC01 - allylestrenol ; Belongs to the class of estren derivative progestogens used in progestogenic hormone preparations.