Sign Out
Oral
Infected animal bites
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc |
| 10-30 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Cystitis
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc |
| 10-30 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Acute bacterial sinusitis
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc |
| 10-30 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Upper respiratory tract infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc |
| 10-30 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Ear, nose and/or throat infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc |
| 10-30 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Genitourinary infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc |
| 10-30 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Skin and soft tissue infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc |
| 10-30 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Pyelonephritis
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc |
| 10-30 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Intra-abdominal infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc |
| 10-30 | Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Lower respiratory tract infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta |
| 10-30 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125 |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Osteomyelitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta |
| 10-30 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125 |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Bone and joint infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta |
| 10-30 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125 |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Community-acquired pneumonia
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta |
| 10-30 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125 |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Acute otitis media
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta |
| 10-30 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125 |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Oral
Acute exacerbations of chronic bronchitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta |
| 10-30 | Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125 |
| <30 | As extended-release tab: Contraindicated. |
Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.
Intravenous
Acute exacerbations of chronic bronchitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Community-acquired pneumonia
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Bone and joint infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Genitourinary infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Ear, nose and/or throat infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Osteomyelitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Intra-abdominal infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Lower respiratory tract infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Pyelonephritis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Skin and soft tissue infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Upper respiratory tract infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Cystitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Infected animal bites
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
| CrCl (ml/min) | Dosage Recommendation |
| <10 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly. |
| 10-30 | Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly. |
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Intravenous
Prophylaxis of surgical infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion In major surgical procedures involving the head and neck, cardiac, gastrointestinal tract, biliary tract, renal, joint replacement, and pelvic cavity: For procedures <1 hour duration: 1,000 mg/200 mg to 2,000 mg/200 mg given at induction of anaesthesia; For procedures >1 hour duration: 1,000 mg/200 mg to 2,000 mg/200 mg given at induction of anaesthesia, then up to 3 more 1,000 mg/200 mg doses in 24 hours. Administer normal IV or oral treatment course post-operatively, if clear signs of infection at operation is observed.
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
