Oral
Essential thrombocythaemia
Adult: In patients who are intolerant to or unresponsive to other therapy, and in thrombocythaemia secondary to myeloproliferative disorders: Initially, 1 mg daily in 2 divided doses. Alternative initial dose: 2 mg daily in 2-4 divided doses. Maintain initial dose for at least 1 week, then titrate by not more than 0.5 mg daily at weekly intervals until the platelet count is maintained within normal range. Max: 2.5 mg/dose or 10 mg daily. Maintenance: 1-3 mg daily.
Child: ≥7 years Initially, 0.5 mg daily for 1 week, increase in increments of 0.5 mg daily at weekly intervals until the platelet count is maintained within normal range. Usual maintenance dose: 2.5 mg/dose or 10 mg daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
<50 | Contraindicated. |