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Dosage/Direction for Use
Topical/Cutaneous Skin fungal infections Adult: Skin mycoses caused by dermatophytes, yeasts, moulds, and other fungi (e.g. tinea pedis, tinea manuum, tinea corporis, tinea cruris): As 1% cream: Apply thinly onto the affected area(s) once daily, preferably at night. Treatment duration: 2-4 weeks. |
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Contraindications
Hypersensitivity. Treatment of nail, scalp and vaginal infections, and infants with diaper rash.
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Special Precautions
Patient with history of hypersensitivity reactions to other imidazole antifungal agents (e.g. clotrimazole, econazole, miconazole). Pregnancy and lactation. Patient Counselling Avoid contact with eyes and mucous membranes.
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Adverse Reactions
Significant: Hypersensitivity reactions.
General disorders and administration site conditions: Application site pain and peripheral oedema.
Skin and subcutaneous tissue disorders: Rash, pruritus, erythema, urticaria, dry skin, skin irritation and maceration, skin burning sensation, eczema, blister, skin exfoliation, contact and allergic dermatitis.
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Drug Interactions
May possibly lead to an increase in INR of warfarin.
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Action
Bifonazole is an imidazole derivative broad spectrum antifungal agent. It inhibits the biosynthesis of ergosterol, thereby resulting in structural and functional impairment of the cytoplasmic membrane.
Absorption: Well absorbed into infected skin layers; increased in inflamed skin. Excretion: Via urine (45%); faeces (40%). Elimination half-life: Biphasic: 8 hours and 50 hours. |
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Storage
Topical/Cutaneous: Store below 30°C.
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CIMS Class
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ATC Classification
D01AC10 - bifonazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
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