Parenteral
Respiratory tract infections
Adult: Mild cases: 250-500 mg 8 hourly. Moderate to severe cases: 500-1,000 mg 6-8 hourly. Severe, life-threatening cases: 1,000-1,500 mg 6 hourly. Max: 1,200 mg daily. Doses are given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: >1 month Mild to moderately severe cases: 25-50 mg/kg daily in 3 or 4 divided doses. Severe cases: Up to 100 mg/kg daily may be given in 3 or 4 divided doses. Doses are given via deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Child: CrCl 5-20 mL/min: 10% of the normal daily dose 24 hourly. CrCl 20-40 mL/min: 25% of the normal daily dose in 2 divided doses. CrCl 40-70 mL/min: 60% of the normal daily dose in 2 divided doses. Dosage recommendations apply after an initial loading dose is administered. Adult: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Adult: Half the usual dose 18-24 hourly. |
11-34 | Adult: Half the usual dose 12 hourly. |
35-54 | Adult: Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.
Parenteral
Skin and soft tissue infections
Adult: Mild cases: 250-500 mg 8 hourly. Moderate to severe cases: 500-1,000 mg 6-8 hourly. Severe, life-threatening cases: 1,000-1,500 mg 6 hourly. Max: 1,200 mg daily. Doses are given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: >1 month Mild to moderately severe cases: 25-50 mg/kg daily in 3 or 4 divided doses. Severe cases: Up to 100 mg/kg daily may be given in 3 or 4 divided doses. Doses are given via deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Child: CrCl 5-20 mL/min: 10% of the normal daily dose 24 hourly. CrCl 20-40 mL/min: 25% of the normal daily dose in 2 divided doses. CrCl 40-70 mL/min: 60% of the normal daily dose in 2 divided doses. Dosage recommendations apply after an initial loading dose is administered. Adult: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Adult: Half the usual dose 18-24 hourly. |
11-34 | Adult: Half the usual dose 12 hourly. |
35-54 | Adult: Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.
Parenteral
Septicaemia
Adult: Mild cases: 250-500 mg 8 hourly. Moderate to severe cases: 500-1,000 mg 6-8 hourly. Severe, life-threatening cases: 1,000-1,500 mg 6 hourly. Max: 1,200 mg daily. Doses are given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: >1 month Mild to moderately severe cases: 25-50 mg/kg daily in 3 or 4 divided doses. Severe cases: Up to 100 mg/kg daily may be given in 3 or 4 divided doses. Doses are given via deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Child: CrCl 5-20 mL/min: 10% of the normal daily dose 24 hourly. CrCl 20-40 mL/min: 25% of the normal daily dose in 2 divided doses. CrCl 40-70 mL/min: 60% of the normal daily dose in 2 divided doses. Dosage recommendations apply after an initial loading dose is administered. Adult: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Adult: Half the usual dose 18-24 hourly. |
11-34 | Adult: Half the usual dose 12 hourly. |
35-54 | Adult: Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.
Parenteral
Genitourinary infections
Adult: Mild cases: 250-500 mg 8 hourly. Moderate to severe cases: 500-1,000 mg 6-8 hourly. Severe, life-threatening cases: 1,000-1,500 mg 6 hourly. Max: 1,200 mg daily. Doses are given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: >1 month Mild to moderately severe cases: 25-50 mg/kg daily in 3 or 4 divided doses. Severe cases: Up to 100 mg/kg daily may be given in 3 or 4 divided doses. Doses are given via deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Child: CrCl 5-20 mL/min: 10% of the normal daily dose 24 hourly. CrCl 20-40 mL/min: 25% of the normal daily dose in 2 divided doses. CrCl 40-70 mL/min: 60% of the normal daily dose in 2 divided doses. Dosage recommendations apply after an initial loading dose is administered. Adult: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Adult: Half the usual dose 18-24 hourly. |
11-34 | Adult: Half the usual dose 12 hourly. |
35-54 | Adult: Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.
Parenteral
Endocarditis
Adult: Mild cases: 250-500 mg 8 hourly. Moderate to severe cases: 500-1,000 mg 6-8 hourly. Severe, life-threatening cases: 1,000-1,500 mg 6 hourly. Max: 1,200 mg daily. Doses are given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: >1 month Mild to moderately severe cases: 25-50 mg/kg daily in 3 or 4 divided doses. Severe cases: Up to 100 mg/kg daily may be given in 3 or 4 divided doses. Doses are given via deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Child: CrCl 5-20 mL/min: 10% of the normal daily dose 24 hourly. CrCl 20-40 mL/min: 25% of the normal daily dose in 2 divided doses. CrCl 40-70 mL/min: 60% of the normal daily dose in 2 divided doses. Dosage recommendations apply after an initial loading dose is administered. Adult: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Adult: Half the usual dose 18-24 hourly. |
11-34 | Adult: Half the usual dose 12 hourly. |
35-54 | Adult: Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.
Parenteral
Bone and joint infections
Adult: Mild cases: 250-500 mg 8 hourly. Moderate to severe cases: 500-1,000 mg 6-8 hourly. Severe, life-threatening cases: 1,000-1,500 mg 6 hourly. Max: 1,200 mg daily. Doses are given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: >1 month Mild to moderately severe cases: 25-50 mg/kg daily in 3 or 4 divided doses. Severe cases: Up to 100 mg/kg daily may be given in 3 or 4 divided doses. Doses are given via deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Child: CrCl 5-20 mL/min: 10% of the normal daily dose 24 hourly. CrCl 20-40 mL/min: 25% of the normal daily dose in 2 divided doses. CrCl 40-70 mL/min: 60% of the normal daily dose in 2 divided doses. Dosage recommendations apply after an initial loading dose is administered. Adult: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Adult: Half the usual dose 18-24 hourly. |
11-34 | Adult: Half the usual dose 12 hourly. |
35-54 | Adult: Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.
Parenteral
Biliary tract infections
Adult: Mild cases: 250-500 mg 8 hourly. Moderate to severe cases: 500-1,000 mg 6-8 hourly. Severe, life-threatening cases: 1,000-1,500 mg 6 hourly. Max: 1,200 mg daily. Doses are given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: >1 month Mild to moderately severe cases: 25-50 mg/kg daily in 3 or 4 divided doses. Severe cases: Up to 100 mg/kg daily may be given in 3 or 4 divided doses. Doses are given via deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Child: CrCl 5-20 mL/min: 10% of the normal daily dose 24 hourly. CrCl 20-40 mL/min: 25% of the normal daily dose in 2 divided doses. CrCl 40-70 mL/min: 60% of the normal daily dose in 2 divided doses. Dosage recommendations apply after an initial loading dose is administered. Adult: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Adult: Half the usual dose 18-24 hourly. |
11-34 | Adult: Half the usual dose 12 hourly. |
35-54 | Adult: Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.
Parenteral
Acute uncomplicated urinary tract infections
Adult: 1,000 mg 12 hourly to be given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Max: 1,200 mg daily. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Half the usual dose 18-24 hourly. |
11-34 | Half the usual dose 12 hourly. |
35-54 | Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.
Parenteral
Pneumonia
Adult: 500 mg 12 hourly to be given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Max: 1,200 mg daily. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Half the usual dose 18-24 hourly. |
11-34 | Half the usual dose 12 hourly. |
35-54 | Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.
Parenteral
Prophylaxis of surgical infections
Adult: Peri-operative dose: 1,000 mg given 30-60 minutes prior to surgery. For long surgeries (≥2 hours): Additional doses of 500-1,000 mg may be given during the surgery. Post-operative doses: 500-1,000 mg 6-8 hourly for 24 hours. Doses are given via deep IM inj, slow IV inj over 3-5 minutes, or intermittent or continuous IV infusion. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Renal impairment: Dosage recommendations apply after an initial loading dose is administered.
CrCl (ml/min) | Dosage Recommendation |
≤10 | Half the usual dose 18-24 hourly. |
11-34 | Half the usual dose 12 hourly. |
35-54 | Usual dose 8 hourly. |
Reconstitution: Add 2 mL, 2.5 mL, or 5 mL of sterile water for inj to the vial labelled as 500 mg, 1 g, or 2 g respectively, to provide a solution containing approx 225 mg/mL, 330 mg/mL or 333 mg/mL. Further dilute the reconstituted solution in approx 10 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV solution for IV infusion. Instructions for reconstitution may vary among countries and individual products. Refer to specific product guidelines.
Incompatibility: Incompatible with ascorbic acid, amikacin disulfate, amobarbital Na, bleomycin sulfate, Ca gluceptate, Ca gluconate, cimetidine hydrochloride, colistimethate Na, erythromycin gluceptate, kanamycin sulfate, oxytetracycline hydrochloride, pentobarbital Na, polymyxin-B sulfate, and tetracycline hydrochloride.