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Dosage/Direction for Use
Oral Bladder spasms due to catheterisation, Dysuria, Urinary incontinence, urgency and frequency Adult: 100-200 mg 3-4 times daily. May reduce when symptoms improve. Child: ≥12 yr Same as adult dose. |
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Administration
May be taken with or without food.
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Contraindications
Pyloric or duodenal obstruction, obstructive intestinal lesions or ileus, achalasia, GI haemorrhage, and obstructive uropathies of the lower urinary tract.
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Special Precautions
Patient w/ suspected glaucoma (esp closed angle glaucoma); serious, uncontrolled, obstructive disorders of the lower urinary tract. Childn. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness and blurred vision, if affected, do not drive or operate machinery.
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Adverse Reactions
Nervous: Drowsiness, headache, vertigo, nervousness, confusion.
CV: Palpitation, tachycardia.
GI: Nausea, vomiting, dry mouth/throat, abdominal pain, constipation.
Resp: Reduced bronchial secretions.
Genitourinary: Dysuria.
Haematologic: Leucopenia, eosinophilia.
Ophthalmologic: Increased intraocular tension, accommodation disturbance, blurred vision, photophobia.
Dermatologic: Dryness, flushing, urticaria and other dermatoses.
Others: Hyperpyrexia.
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Drug Interactions
Increased CNS effects w/ other sedative agents.
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Food Interaction
Increased CNS effects w/ alcohol.
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Action
Flavoxate is a tertiary amine w/ direct relaxant effect on smooth muscles through inhibition of phosphodiesterase, thereby reducing symptoms associated w/ bladder spasticity. It also has antimuscarinic effects.
Onset: 55 min. Absorption: Readily absorbed from the GI tract. Time to peak plasma concentration: Approx 2 hr. Metabolism: Rapidly metabolised mainly to the active metabolite methyl flavone carboxylic acid (MFCA). Excretion: Via urine (approx 50-60%, as MFCA). |
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Storage
Oral: Store between 20-25°C. Protect from light.
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CIMS Class
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ATC Classification
G04BD02 - flavoxate ; Belongs to the class of urinary antispasmodics.
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