Oral
Alzheimer's dementia
Adult: For symptomatic treatment of mild to moderately severe cases: As conventional tab/oral susp: Initially, 4 mg bid for 4 weeks, increase to 8 mg bid for at least 4 weeks, if tolerated. May further increase to 12 mg bid according to individual response and tolerability. As modified-release cap: Initially, 8 mg once daily, preferably in the morning for 4 weeks, increase to 16 mg once daily for at least 4 weeks. May further increase to 24 mg once daily according to individual response and tolerability. Reassess dosing, clinical benefit and individual tolerance within the 1st 3 months of treatment and regularly thereafter.
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
<9 | Contraindicated. |
Special Populations: Galantamine is primarily metabolised by CYP2D6 and CYP3A4 isoenzymes to inactive metabolites. Individuals with reduced CYP2D6 activity, known as CYP2D6 poor metabolisers, may experience an increased galantamine exposure. The prevalence of CYP2D6 poor metabolisers is estimated at approx 7% of the normal population. CYP2D6 poor metabolisers Patient may experience increased galantamine exposure. Although results of researches indicate an increased exposure, CYP2D6 poor metabolisers do not require dosage adjustments since the galantamine dose is titrated according to individual tolerability. Pharmacogenetic testing prior to galantamine treatment initiation has not been addressed by currently available references.