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Dosage/Direction for Use
Ophthalmic Bacterial conjunctivitis Adult: As 0.3% solution: Instil 1 drop 2 hourly into the affected eye(s) while awake (Max: 8 times per day) on Days 1 and 2, then reduce to 1 drop up to 4 times daily on Days 3-7. As 0.5% solution: Instil 1 drop into the affected eye(s) 2 hourly while awake (Max: 8 times per day) on Day 1, then reduce to 1 drop 2-4 times daily on Days 2-7. Child: ≥1 year As 0.5% solution: Same as adult dose. |
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Contraindications
Hypersensitivity to gatifloxacin or other quinolones.
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Special Precautions
Not intended for direct application into the anterior chamber of the eye. Pregnancy and lactation. Patient Counselling Remove contact lenses before administration and wait for 10-15 minutes before reinserting soft contact lenses.
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Adverse Reactions
Significant: Hypersensitivity reactions (e.g. urticaria, itching); fungal or bacterial superinfection (prolonged use).
Eye disorders: Conjunctival irritation, increased lacrimation, keratitis, papillary conjunctivitis, worsening of conjunctivitis, eye pain.
Gastrointestinal disorders: Dysgeusia.
Potentially Fatal: Hypersensitivity reactions including anaphylactic reactions, angioedema (including pharyngeal, laryngeal or facial oedema), or dyspnoea. Rarely, Stevens-Johnson syndrome. |
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Action
Gatifloxacin is a fluoroquinolone antibacterial that acts by inhibiting DNA synthesis in susceptible organisms via inhibition of both DNA gyrase (an essential enzyme for bacterial replication, transcription and repair) and topoisomerase IV (an enzyme that plays a key role in bacterial cell division).
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Storage
Ophthalmic: Store between 15-25°C. Protect from freezing.
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CIMS Class
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ATC Classification
J01MA16 - gatifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
S01AE06 - gatifloxacin ; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections. |
