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Dosage/Direction for Use
Oral Osteoarthritis of the knee Adult: Monotherapy or adjunctive treatment for the symptomatic relief of mild to moderate cases: As glucosamine hydrochloride tab/effervescent tab/cap: Usual dose: 1,250 mg once daily, as a single dose or in 2 divided doses. As glucosamine sulfate tab/powder for oral solution: Usual dose: 1,500 mg once daily, as a single dose or in 2-3 divided doses. Re-evaluate treatment if relief of symptoms is not achieved after 2-3 months. |
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Administration
Should be taken with food. Preferably taken at meals.
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Contraindications
Hypersensitivity to glucosamine and shellfish. Children.
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Special Precautions
Patient with impaired glucose tolerance, diabetes mellitus, asthma; known risk factors for CV disease. Rule out the presence of other joint diseases. Not indicated for the treatment of acute painful symptoms. Renal and hepatic impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness or drowsiness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor blood glucose levels prior to and periodically thereafter (in patients with impaired glucose tolerance); cholesterol levels (in at risk for CV disease).
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Adverse Reactions
Significant: Asthma exacerbation, hypercholesterolaemia, worsened blood glucose control.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, constipation, abdominal pain, heartburn, flatulence, dyspepsia.
General disorders and administration site conditions: Fatigue, peripheral oedema.
Hepatobiliary disorders: Jaundice.
Investigations: Elevated hepatic enzymes.
Nervous system disorders: Headache, dizziness, drowsiness.
Skin and subcutaneous tissue disorders: Rash, pruritus, erythema, angioedema, urticaria.
Vascular disorders: Flushing.
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Overdosage
Symptoms: Headache, vertigo, dizziness, disorientation, arthralgia, nausea, vomiting, diarrhoea, and constipation. Management: Supportive treatment.
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Drug Interactions
May increase the anticoagulant effects of warfarin and acenocoumarol. May increase the absorption and serum levels of tetracyclines.
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Action
Glucosamine is a natural substance found in mucoproteins, chitin, and mucopolysaccharides. It stimulates the synthesis of glycosaminoglycans which are responsible for the formation of cartilage in the body. It may be used as a health supplement in the management of musculoskeletal and joint disorders for its supposed chondroprotective activity.
Distribution: Volume of distribution: Approx 2.5-5 L. Metabolism: Extensively metabolised in the liver. Excretion: Via urine. |
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Storage
Oral: Store below 30°C. Protect from light and moisture.
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CIMS Class
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ATC Classification
M01AX05 - glucosamine ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
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