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Dosage/Direction for Use
Oral Cerebrovascular and peripheral vascular disease Adult: 10-20 mg 3 or 4 times daily. |
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Administration
May be taken with or without food. May be taken w/ meals, milk or antacids to minimise GI discomfort.
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Contraindications
Recent arterial haemorrhage.
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Special Precautions
Pregnancy and lactation. Not intended to be given immediately postpartum.
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Adverse Reactions
Significant: Severe rash.
Nervous: Trembling, nervousness, weakness, dizziness.
CV: Palpitation, tachycardia, chest pain, hypotension, flushing.
GI: Abdominal distress, nausea, vomiting, intestinal distention.
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Action
Isoxsuprine, a β-agonist, increases muscle blood flow by directly relaxing the vascular smooth muscle.
Absorption: Well absorbed from the GI tract. Time to peak plasma concentration: Approx 1 hr. Distribution: Crosses the placenta. Excretion: Excreted via urine as conjugates. Plasma elimination half-life: Approx 1.5 hr. |
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Storage
Oral: Store between 15-30°C.
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ATC Classification
C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative agents. Used as peripheral vasodilators.
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