Oral
HIV infection
Adult: 150 mg bid or 300 mg once daily, in combination w/ other antiretrovirals.
Child: As soln: >3 mth <14 kg: 4 mg/kg bid. As tab: 14-21 kg: 75 mg bid; 22-30 kg: 75 mg in the morning and 150 mg at night; >30 kg: 150 mg bid. Max: 300 mg daily. Doses are given in combination w/ other antiretrovirals.
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
<5 | 1st dose 50 mg, then 25 mg once daily. |
5-14 | 1st dose 150 mg, then 50 mg once daily. |
15-29 | 1st dose 150 mg, then 100 mg once daily. |
30-49 | 1st dose 150 mg, then 150 mg once daily. |
Oral
Chronic hepatitis B
Adult: 100 mg once daily. For patients w/ concomitant HIV infection: 150 mg bid or 300 mg once daily.
Child: 2-17 yr 3 mg/kg once daily. Max: 100 mg daily.
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
<5 | 1st dose 35 mg, then 10 mg once daily. |
5-14 | 1st dose 35 mg, then 15 mg once daily. |
15-29 | 1st dose 100 mg, then 25 mg once daily. |
30-49 | 1st dose 100 mg, then 50 mg once daily. |