Dosage/Direction for Use
Oral Acute alcohol intoxication Adult: 500-1000 mg daily. Oral Alcoholic fatty liver Adult: 1000 mg daily. Oral Supportive treatment of acute and chronic liver diseases Adult: 1000 mg daily. Parenteral Acute alcohol intoxication Adult: 300-600 mg daily IM/IV. Parenteral Alcoholic fatty liver Adult: 300 mg daily IM/IV. Parenteral Supportive treatment of acute and chronic liver diseases Adult: 300 mg daily IM/IV. |
Contraindications
Pregnancy and lactation.
|
Drug Interactions
May reduce effects of levodopa; administer levodopa with a dopa-decarboxylase inhibitor to minimise interaction.
|
Action
Metadoxine enhances the elimination of alcohol from blood and tissues, which leads to faster recovery from alcohol intoxication. In the early stages of alcoholic liver disease, metadoxine has been suggested to prevent the redox imbalance of the hepatocytes and to prevent TNF-α induction.
|
ATC Classification
A05BA09 - metadoxine
|