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Dosage/Direction for Use
Oral Anxiety Adult: 10 mg daily in 2 divided doses; may increase to 20 mg daily in severe cases. |
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Administration
May be taken with or without food.
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Contraindications
Myasthenia gravis, acute narrow-angle glaucoma. Pregnancy.
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Special Precautions
Patient with CV disease, blood dyscrasias. Hepatic impairment.
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Adverse Reactions
Blood and lymphatic system disorders: Rarely, bone marrow depression.
Cardiac disorders: Palpitations, tachycardia.
Gastrointestinal disorders: Gastrointestinal disorders.
Hepatobiliary disorders: Rarely, liver damage.
Musculoskeletal and connective tissue disorders: Muscle weakness.
Nervous system disorders: Ataxia, dizziness, drowsiness.
Psychiatric disorders: Confusion.
Skin and subcutaneous tissue disorders: Rash.
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Drug Interactions
Enhances the sedative effects of other CNS depressant drugs (e.g. opioids, sedating antihistamines, barbiturates).
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Food Interaction
Increases the CNS depressant effects of alcohol.
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Action
Pinazepam, a long-acting benzodiazepine, has general properties similar to diazepam but with less toxicity. Its action mainly involves modification in the limbic system region. Pinazepam appears to be associated with a particularly low hypnotic effect and a limited motor coordination impairment. It also shows less cortical activity at the anxiolytic level than does diazepam on EEG.
Absorption: Rapidly absorbed from the gastrointestinal tract. Metabolism: Metabolised via N-1 dealkylation and C-3 hydroxylation. |
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CIMS Class
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ATC Classification
N05BA14 - pinazepam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
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