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Dosage/Direction for Use
Oral Gastric ulcer, Gastritis Adult: 100 mg tid, usually in the morning, evening and before bedtime. |
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Administration
May be taken with or without food.
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Special Precautions
Elderly. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness or dizziness, if affected, do not drive or operate machinery.
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Adverse Reactions
Significant: Dizziness, drowsiness, thrombocytopenia, leucopenia, hypersensitivity and anaphylactoid reactions (e.g. hives, rash, itching, eczema), shock, jaundice. Rarely, liver dysfunction.
Gastrointestinal disorders: Constipation, dry mouth, diarrhoea, nausea, vomiting, heartburn, abdominal pain, belching, sensation of abdominal enlargement, taste abnormality.
Investigations: Increased AST, ALT, alkaline phosphatase, or BUN levels.
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Action
Rebamipide is postulated to increase prostaglandin E2 in gastric mucosa and elevate gastric mucous, gastric mucosal blood flow and secretion of gastric alkaline. It also stimulates gastric mucosal cell growth and decreases gastric mucosa injury.
Absorption: Time to peak plasma concentration: 2 hours. Distribution: Plasma protein binding: 98.4-98.6%. Excretion: Via urine (approx 10% as unchanged drug). |
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Storage
Oral: Store below 30°C.
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CIMS Class
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ATC Classification
A02BX14 - rebamipide ; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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