Oral
Postmenopausal osteoporosis
Adult: As conventional tab: Treatment and prophylaxis: 5 mg once daily. Alternatively, 35 mg once weekly, or 75 mg taken on 2 consecutive days per month, or 150 mg once monthly. As delayed-release tab: Treatment: 35 mg once weekly. Re-evaluate the need for continued therapy periodically according to individual benefits and potential risks.
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
<30 | Contraindicated. |
Oral
Corticosteroid-induced osteoporosis
Adult: Treatment and prophylaxis in patients who are receiving chronic systemic corticosteroid therapy (prednisone ≥7.5 mg daily or equivalent): As conventional tab: 5 mg once daily. Re-evaluate the need for continued therapy periodically according to individual benefits and potential risks.
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
<30 | Contraindicated. |
Oral
Paget's disease of bone
Adult: As conventional tab: 30 mg once daily for 2 months; may be repeated if necessary after at least 2 months post-treatment observation period. For retreatment, the same dose and duration of therapy may be given.
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
<30 | Contraindicated. |
Oral
Osteoporosis in men
Adult: As conventional tab: 35 mg once weekly. Re-evaluate the need for continued therapy periodically according to individual benefits and potential risks.
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
<30 | Contraindicated. |