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Dosage/Direction for Use
Intramuscular Susceptible Gram-negative and staphylococcal infections Adult: 3 mg/kg daily in 2-3 divided doses. May also be given as IV infusion, if needed. Renal impairment: May need to adjust maintenance doses and/or dosing intervals. Topical/Cutaneous Pyoderma Adult: As 0.1% cream: Apply onto the affected area(s) bid. |
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Contraindications
Hypersensitivity.
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Special Precautions
Renal or liver impairment, myasthenia gravis, parkinsonism, dehydration, hypotension, pregnancy, lactation.
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Adverse Reactions
Ototoxicity, nephrotoxicity, neurotoxicity (peripheral neuropathy, confusion, lethargy, hallucination, convulsion and mental depression, occasional respiratory depression), rarely hypersensitivity reaction.
Potentially Fatal: Acute renal failure especially in combination with other nephrotoxic drugs. |
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Drug Interactions
Plasma levels increased by indometacin. Antihistamines (H1-receptor blocker) may mask early signs of ototoxicity. Incompatible with some β-lactam antibiotics.
Potentially Fatal: Potentiates nephrotoxicity produced by other nephrotoxic drugs including other aminoglycosides, vancomycin and some cephalosporins. Potentiates ototoxicity produced by other aminoglycosides, ethacrynic acid. Ototoxicity potentiated by furosemide. |
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Action
Sisomicin binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.
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CIMS Class
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ATC Classification
J01GB08 - sisomicin ; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.
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