Sodium hyaluronate

Intra-articular
Osteoarthritis of the knee
Adult: As intra-articular inj solution: 20 mg or 25 mg once weekly via inj directly into the knee joint for 3-5 weeks. Dosage and treatment duration recommendations may vary among individual products and between countries (refer to detailed local product guidelines).
Incompatibility: May result in precipitation with disinfectants or other agents containing quaternary ammonium salts (e.g. benzalkonium chloride).

Intraocular
Surgical aid in the anterior segment during cataract extraction and intraocular lens implantation
Adult: As 30 mg/mL intraocular inj solution: Slowly inj a sufficient amount into the anterior chamber of the eye before cataract removal and before the insertion of the intraocular lens. Recommendations may vary among individual products and between countries (refer to detailed local product guidelines).
Incompatibility: May result in precipitation with disinfectants or other agents containing quaternary ammonium salts (e.g. benzalkonium chloride).

Ophthalmic
Dry eye
Adult: As 0.1% or 0.3% ophthalmic solution: Instil 1 drop into the affected eye(s) 5-6 times daily. As 0.18% ophthalmic solution: Instil 1-2 drops into the affected eye(s) as needed. Dosage recommendations may vary among individual products and between countries (refer to detailed local product guidelines).
Incompatibility: May result in precipitation with disinfectants or other agents containing quaternary ammonium salts (e.g. benzalkonium chloride).

Topical/Cutaneous
Skin ulcer
Adult: As topical cream or gel: Apply a thin layer onto a clean and disinfected wound/ulcer bid or tid.
Incompatibility: May result in precipitation with disinfectants or other agents containing quaternary ammonium salts (e.g. benzalkonium chloride).

Topical/Cutaneous
Skin wound
Adult: As topical cream or gel: Apply a thin layer onto a clean and disinfected wound/ulcer bid or tid.
Incompatibility: May result in precipitation with disinfectants or other agents containing quaternary ammonium salts (e.g. benzalkonium chloride).

Hypersensitivity. Infections or skin diseases in the inj site area (intra-articular).

Patient with glaucoma (intraocular); pre-existing chondrocalcinosis, venous or lymphatic stasis is present in the leg (intra-articular). Joint effusion, if present, must be removed prior to inj (intra-articular). Remove sodium hyaluronate completely from the anterior chamber at the end of surgery (intraocular). Pregnancy and lactation. Patient Counselling Intra-articular: Avoid strenuous or prolonged weight-bearing activities for 48 hours after the inj. Topical: Lesions may be covered with a sterile gauze pad or elastic bandage if needed. Monitoring Parameters Intraocular: Closely monitor IOP, particularly in the early postoperative period.

Eye disorders: Blurred vision, blepharitis, eyelid itching, eye irritation, conjunctivitis, keratitis superficialis diffusa, corneal oedema, foreign body sensation, redness or burning sensation of the eye. General disorders and administration site conditions: Inj site pain and inflammation (intra-articular). Immune system disorders: Hypersensitivity reactions. Rarely, anaphylaxis. Investigations: Transient increase in IOP (intraocular). Skin and subcutaneous tissue disorders: Ecchymoses, skin rash.

Sodium hyaluronate, a high molecular weight fraction of purified natural sodium hyaluronic acid, is widely distributed in the extracellular matrix of connective tissues (particularly in the synovial fluid, umbilical cord, skin, and vitreous and aqueous humour of the eye). It acts as a viscoelastic space filler during ophthalmic surgery and functions as a tissue/joint lubricant to regulate the interactions between adjacent tissues. Topically, it protects the skin against abrasion, friction and desiccation.

Intra-articular: Intra-articular inj: Store below 30°C. Do not freeze. Protect from light. Storage recommendations may vary among individual products or between countries (refer to detailed product guidelines). Intraocular: Intraocular inj: Store between 2-25°C. Do not freeze. Protect from light. Storage recommendations may vary among individual products or between countries (refer to detailed product guidelines). Ophthalmic: Ophthalmic solution: Store below 30°C. Storage recommendations may vary among individual products or between countries (refer to detailed product guidelines). Topical/Cutaneous: Topical cream or gel: Store below 30°C. Storage recommendations may vary among individual products or between countries (refer to detailed product guidelines).

Emollients & Skin Protectives / Ophthalmic Lubricants / Other Drugs Acting on Musculo-Skeletal System / Other Eye Preparations