Sign Out
UserName
Profession Email
Profession Email
|
Dosage/Direction for Use
Oral Thiamine deficiency Adult: Mild cases: 50-100 mg daily. Severe cases: Up to 300 mg daily in divided doses. Intramuscular Thiamine deficiency Adult: 10-20 mg tid up to 2 weeks, followed by oral therapy for 1 month. Incompatibility: Alkaline or neutral solutions, oxidising and reducing agents. Parenteral Wernicke-Korsakoff syndrome Adult: Initially, 100 mg via slow IV inj over 10 minutes, then 50-100 mg daily via IM or IV inj until the patient is consuming a regular, balanced diet. Incompatibility: Alkaline or neutral solutions, oxidising and reducing agents. |
|
Administration
Thiamine (vit b1): Should be taken with food.
|
|
Special Precautions
Patient with history of allergic reactions. Pregnancy and lactation.
|
|
Adverse Reactions
Significant: Allergic reactions (e.g. tingling, pruritus, urticaria).
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain.
General disorders and administration site conditions: Injection site pain, local irritation, tenderness, induration.
Potentially Fatal: Serious hypersensitivity reactions (IM/IV). |
|
Drug Interactions
IV dextrose may worsen acute symptoms of thiamine deficiency. May enhance the effect of neuromuscular blocking agents. Diminished therapeutic effect with etamsylate.
|
|
Food Interaction
High carbohydrate diet may increase thiamine requirement.
|
|
Lab Interference
May give false-positive results for uric acid using phosphotungstate method, and for urobilinogen using Ehrlich's reagent. High doses of thiamine may interfere with the spectrophotometric determination of serum theophylline concentrations.
|
|
Action
Thiamine is a water-soluble vitamin. It combines with ATP to form thiamine pyrophosphate, an essential coenzyme in carbohydrate metabolism.
Synonyms: aneurine.
Absorption: Well-absorbed from the gastrointestinal tract after oral administration and rapidly and completely absorbed following IM injection. Distribution: Widely distributed in most body tissues, with highest concentration in the brain, heart, kidney and liver. Enters breastmilk. Metabolism: Metabolised in the liver. Excretion: Via urine as metabolites and unchanged drug. |
|
Storage
Intramuscular: Store below 25°C. Protect from light. Oral: Store below 25°C. Protect from light. Parenteral: Store below 25°C. Protect from light.
|
|
CIMS Class
|
