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The recommended dosage for adults is 100 mg once daily. The dose in children has not yet been established. Treatment discontinuation may be considered when HBe and HBs antigen seroconversion occurs. There is insufficient data to confirm that seroconversion will be sustained once treatment with 3TC-HBV is stopped.
Patient compliance should be monitored while on therapy. If 3TC-HBV is discontinued, patients should be observed carefully as there may be a small risk of exacerbation of hepatitis in some patients.
3TC-HBV should be initiated and monitored by a physician experienced in the management of chronic hepatitis B infection.
