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Pharmacology: Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis positions. It is an anti-cancer drug with biochemical properties similar to bi-functional alkylating agents producing inter-strand and intra-strand cross links in DNA; It is cell-cycle non-specific. After a single i.v. dose, Cisplatin concentrates in liver, kidney and large and small intestines.
It has poor penetration into the CNS. More than 90% of the drug is bound to plasma protein.
The distribution half-life ranges from 58 to 73 hours.
Cisplatin excreted primarily in the urine, although urinary excretion is incomplete with only 27 to 43% of the dose being excreted within the first 5 days post-dose.
