Glaucoma, history of active or chronic gastric ulcer, HTN, osteoporosis, myasthenia gravis, epilepsy, heart failure, history of ulcerative colitis, prostatism, hypothyroidism. Adjust dose of antidiabetic agents in diabetics as it may increase gluconeogenesis & reduce sensitivity to insulin. Prolonged treatment may reduce body resistance to infections. May impair ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
Electrolyte imbalance; musculoskeletal, ophth, metabolic & psychiatric, dermatologic, endocrine & GI disorders. Mild drowsiness, dry mouth, nose & throat, urinary retention, GI disturbances, sedation, dizziness, vertigo.
Concomitant use w/ anticoagulants may increase or reduce prothrombin time. May increase risk of hypokalemia w/ K-sparing diuretics & carbenoxolone. Metabolism of corticosteroid is increased by rifampicin, carbamazepine, phenobarb, phenytoin, primidone, aminoglutethimide, barbiturate. Antagonized hypoglycemic effect of antidiabetic agents. Concomitant use of high-dose corticosteroid w/ phenoterol, pirbuterol, reproterol, rimiterol, ritodrine, salbutamol & high-dose terbutaline may result in hypokalemia. Antagonized hypotension effect of antihypertensive drugs.
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