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There is no evidence that ONDAVELL either induces or inhibits the metabolism of other drugs commonly coadministered with it.
Specific studies have shown that there are no pharmacokinetic interactions when ONDAVELL is administered with alcohol, temazepam, furosemide, tramadol and propofol. Ondansetron is metabolised by multiple hepatic cytochrome P-450 enzymes: CYP3A4, CYP2D6 and CYP1A2. Due to the multiplicity of metabolic enzymes capable of metabolizing ondansetron, enzyme inhibition or reduced activity of one enzyme (e.g. CYP2D6 genetic deficiency) is normally compensated by other enzymes and should result in little or no significant change in overall ondansetron clearance or dose requirement.
Phenytoin, Carbamazepine and Rifampicin: In patients treated with potent inducers of CYP3A4 (i.e. phenytoin, carbamazepine and rifampicin), the oral clearance of ondansetron was increased and ondansetron blood concentrations were decreased.
Tramadol: Ondansetron may reduce the analgesic effect of tramadol.
