Otozambon Special Precautions

Treatment should be discontinued promptly if sensitization or irritation occurs.
Otozambon should be discontinued if general pain of tympanic membrane occurs due to possible toxicity of neomycin.
Frequent use may result in overgrowth of nonsusceptible organisms and fungi.
If the infection does not improve after 1 week, cultures and susceptibility tests should be repeated to verify the identity of organism and to determine whether therapy should be changed. When using neomycin to treat secondary infection in the chronic dermatoses eg, chronic otitis externa or stasis dermatitis, it should be borne in mind that the skin in these conditions is more liable than normal skin to become sensitized to many substances. The manifestation of sensitization to neomycin is skin redness with swelling, dry scaling and itching.
In prolonged use of neomycin, it is advisable to do periodic examination to determine whether treatment should be discontinued or not.
Cross-sensitization may occur in concomitant use with other aminoglycosides. It could be prevented by using one or more antibiotics as follows: Kanamycin, paromomycin, streptomycin and gentamicin.
Otozambon should be used carefully in patients with high fever as this condition may reduce drug potency.
If deterioration signs occur, treatment should be discontinued and future treatment with neomycin be avoided.
Treatment should not be continued for >7 days.
Use in pregnancy & lactation: Topical corticosteroid should be used with caution in pregnant women and nursing mothers.