Mild, moderate, & severe infections in adults (≥18 yr) caused by susceptible strains of designated microorganisms: Acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, complicated skin & skin structure infections, complicated UTI, acute pyelonephritis.
Dosage/Direction for Use
250 or 500 mg PO every 24 hr.
Administration
Should be taken on an empty stomach.
Contraindications
Intolerance to fluoroquinolones, QTc prolongation, epilepsy, history of tendon disorder related to fluoroquinolone administration. Pregnancy & breastfeeding women. Child or growing adolescent.
Decreased absorption w/ Fe or antacids containing Mg or Al; should be taken at least 2 hr before or after levofloxacin administration. Decreased bioavailability w/ sucralfate; should be taken at least 2 hr after levofloxacin administration. Enhanced CNS stimulation & convulsion w/ theophylline, fenbufen or NSAIDs. Inhibited secretion w/ probenecid & cimetidine.
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