Not indicated for the maintenance treatment of melasma. Hyperpigmentation conditions other than melasma of the face. Avoid sunlight/UV light exposure. Use sunscreen of SPF ≥30. Wear protective clothing. Change to non-hormonal forms of birth control, if hormonal methods are used. Anaphylactic symptoms & life-threatening asthmatic episodes in susceptible people. Exogenous ochronosis in Black, Caucasians & Hispanics. Patients with skin types V & VI. Avoid contact w/ eyes, nose, or angles of the
mouth. Carcinogenicity, mutagenicity & impairment of fertility. Pregnancy & lactation.