History of asthma attack, bronchial asthma, bronchospasm, acute rhinitis, nasal polyp, urticaria, or angioneurotic edema; active or suspected gastric ulcer, chronic dyspepsia, gastric bleeding or other active bleeding, Crohn's disease or ulcerative colitis, severe heart failure, moderate-severe kidney dysfunction (CrCl <50 mL/min), severe liver impairment (Child Pugh score 10-15); hemorrhagic diathesis & other coagulation disorders or receiving anticoagulant therapy; neuraxial (intrathecal or epidural) administration. Pregnancy & lactation.