SC Adult RA 40 mg every wk. May be increased to 40 mg every wk or 80 mg every other wk in patient not taking concomitant MTX.
Psoriatic arthritis, axial spondyloarthritis (AS & nr-axSpA) 40 mg every other wk.
Plaque psoriasis Adult Initially 80 mg followed by 40 mg every other wk starting 1 wk after initial dose. May be increased to 40 mg every wk or 80 mg every other wk. Dose may be subsequently reduced to 40 mg every other wk if adequate response is achieved.
Paed 4-17 yr, ≥30 kg Initially 40 mg, followed by 40 mg every other wk starting 1 wk after initial dose,
15 to <30 kg Initially 20 mg, followed by 20 mg every other wk starting 1 wk after initial dose.
Crohn's disease Adult Induction: Initially 80 mg at wk 0 followed by 40 mg at wk 2. For more rapid response: 160 mg at wk 0 (160 mg in 1 day or 80 mg daily for 2 consecutive days) & 80 mg at wk 2. After induction, 40 mg every other wk. May be increased to 40 mg every wk or 80 mg every other wk.
Paed 6-17 yr, ≥40 kg Induction: 80 mg at wk 0 & 40 mg at wk 2. For more rapid response: 160 mg at wk 0 & 80 mg at wk 2. Maintenance: 40 mg every other wk starting wk 4,
<40 kg Induction: 40 mg at wk 0 & 20 mg at wk 2. For more rapid response: 80 mg at wk 0 & 40 mg at wk 2. Maintenance: 20 mg every other wk starting wk 4.
Moderate to severe ulcerative colitis 160 mg at wk 0 (160 mg in 1 day or 80 mg daily for 2 consecutive days) & 80 mg at wk 2. After induction, 40 mg every other wk. May be increased to 40 mg every wk or 80 mg every other wk.
Paed 6-17 yr, ≥40 kg Induction: 160 mg at wk 0 & 80 mg at wk 2. Maintenance: 80 mg every other wk or 40 mg every wk starting wk 4,
<40 kg Induction: 80 mg at wk 0 & 40 mg at wk 2. Maintenance: 40 mg every other wk or 20 mg every wk starting wk 4.
HS Initially 160 mg at Day 1 (160 mg in 1 day or 80 mg daily for 2 consecutive days), followed by 80 mg 2 wk later at Day 15. Continue w/ 40 mg every wk or 80 mg every other wk on Day 29.
Adolescent from 12 yr, at least 30 kg 80 mg at wk 0, followed by 40 mg every other wk at wk 1. May be increased to 40 mg every wk or 80 mg every other wk in patient w/ inadequate response.
Uveitis Initially 80 mg followed by 40 mg every other wk starting 1 wk after initial dose.
Paed ≥2 yr, ≥30 kg 40 mg every other wk in combination w/ MTX. Loading dose: 80 mg 1 wk prior to maintenance therapy,
<30 kg 20 mg every other wk in combination w/ MTX. Loading dose: 40 mg 1 wk prior to maintenance therapy.
JIA Paed from 2 yr, ≥30 kg 40 mg every other wk,
10 to <30 kg 20 mg every other wk.
Enthesitis-related arthritis Paed from 6 yr, ≥30 kg 40 mg every other wk,
15 to <30 kg 20 mg every other wk.