Allergy w/ peanut & soya. Not for protection against HIV infections or other STD. Increased risk of venous or arterial thromboembolism; increasing age, +ve family history of venous or arterial thromboembolism, obesity; dyslipoproteinaemia, HTN, valvular heart disease, atrial fibrillation, migraine, smoking; varicose veins, advanced stage phlebitis & thrombosis, existence of heart disease, blood clotting disorders. Increased risk of cervical or breast cancer. Hypertriglyceridaemia; DM, SLE, haemolytic uraemic syndrome, Crohn's disease & ulcerative colitis; chloasma; hereditary angioedema; endogenous depression or epilepsy; irregular bleeding. Monitor BP & perform physical exam prior to therapy. Prolonged immobilization, major surgery or trauma, any leg surgery. Premature epiphyses closure. Concomitant use of St. John's wort, ombitasvir/paritaprevir/ritonavir & dasabuvir w/ or w/o ribavirin. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Active or chronic hepatic disease. Discontinue use if jaundice due to pregnancy or use of steroids occurs or cholestatic pruritus develops. Not indicated during pregnancy. Not to be used during lactation.
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