Specific reversal agent for dabigatran & in patients treated w/ dabigatran when rapid reversal of anticoagulant effects is required for emergency surgery/urgent procedures or life-threatening or uncontrolled bleeding.
5 g (2 x 2.5 g/50 mL) IV as 2 consecutive infusions over 5-10 min each or as bolus inj. Bleeding recurrence/potential life-threatening re-bleeding/2nd emergency surgery/urgent procedure w/ prolonged clotting time 2nd 5-g dose may beconsidered. Restarting antithrombotic therapy Reinitiated after 24 hr & other antithrombotic therapy eg, LMWH may be started at any time if clinically stable & adequate hemostasis has been achieved.
View Praxbind overdosage for action to be taken in the event of an overdose.
Special Precautions
Discontinue use if anaphylactic reaction or other serious allergic reaction occurs. Thrombotic risk of underlying disease. Patients on controlled Na diet. Fructose intolerance. Consider transient proteinuria for urine testing. Pregnancy & lactation. Childn <18 yr.
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 50 mg_mL1c1162b3-fe53-4a8c-a09c-af9a009642fa.GIF)
