Discontinue use if subacute cutaneous lupus erythematosus occurs. Exclude malignancy in presence of alarming symptom eg, significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anaemia or melaena. Increased risk of GI infections caused by bacteria eg, Salmonella, Campylobacter; hip, wrist & spine fracture;
Clostridium difficile-associated diarrhea. Severe hypomagnesaemia; vit B
12 malabsorption due to hypo- or achlorhydria. Discontinue use 5 days prior to chromogranin A measurements. Ensure adequate intake of vit D & Ca. Long-term & high-dose use. Not recommended to be co-administered w/ atazanavir. Concomitant use w/ digoxin or drugs causing hypomagnesaemia eg, diuretics. May affect ability to drive & use machines. Severe hepatic impairment. Not to be used during pregnancy. Lactation.
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