Patients with Normal Renal Function: See Table 1.
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
Patients with Impaired Renal Function: See Table 2.
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
When only the serum creatinine is known, the following formula may be used to estimate creatinine clearance: See equation.
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
The serum creatinine should represent a steady state of renal function.
Patients with Impaired Liver Function: No adjustment of dosage is required since levofloxacin is not metabolized to any relevant extent by liver and is mainly excreted by kidneys.
Elderly: No adjustment is required in the elderly, other than that imposed by consideration of renal function.