View Tirase overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to diacerein or previous hypersensitivity to anthraquinone derivatives. Previous episode of enterocolic disturbances & IBS. Combined use w/ laxatives. Severe renal & hepatic impairment.
Conduct complete blood & liver enzyme tests & urinalysis every 6 mth. Increased absorption w/ food. Decreased bioavailability w/ severe nutritional deficiencies. Not to be taken concomitantly w/ laxatives. Not recommended during pregnancy & lactation & in childn.
Not to be administered w/ drugs that modify intestinal transit &/or quality of intestinal content eg, excess fibres or phytates. Avoid concomitant use w/ Al &/or Mg hydroxide-containing products. May increase enterocolic events w/ antibiotic &/or chemotherapy.