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Signs and Symptoms of Overdose: Chronic overdose has led to T-cell defects in one patient. There have been instances of patients abusing Paracetamol for its purging effect in high dosage.
Treatment: Treatment of Paracetamol overdose involves gastric lavage and administration of acetylcysteine (or sometimes methionine) to increase glutathione stores and perhaps stimulate the non-toxic metabolism of Paracetamol.
