Aero-Vent

Salbutamol sulfate.

Each nebulizing solution contains salbutamol (as sulfate) 2.5 mg.
Each multidose inhaler contains 100 mcg salbutamol sulfate per actuation.

Bronchodilator.
Salbutamol is a β-adrenergic stimulant which has a highly selective action on the receptors in bronchial muscle and in therapeutic doses, it has little or no action on the cardiac receptors.

Management of reversible airway obstruction as in asthma and in some patients with chronic obstructive pulmonary disease.

Nebulizing soln: Adult & childn: 2.5-5 mg. May repeat four times a day by nebulizer. Delivery of aerosol may be by face mask of "T" piece. Use undiluted. For prolonged delivery time, dilute with sterile water or normal saline for injection
MDI: Adult & elderly: Relief of acute asthma symptoms including bronchospasm: Initially one inhalation as single dose. May be increased to two inhalations.
Prevention of allergen- or exercise-induced symptoms Two inhalations 10-15 minute before exertion.
Chronic therapy: Two inhalations up to four times a day. Maximum dose: 8 inhalations per day.
Administration: Directions For Use: Aero-Vent should be used with a nebulizer only, under the direction of a physician. It is not to be injected or administered orally.
To open the nebules, twist off the cap. Squeeze the content into the reservoir of the nebulizing chamber. Discard the nebules after use.

The preferred antidote to overdosage with salbutamol 2.5-mg nebules is a cardioselective β-blocking agent, but β-blocking drugs should be used with caution in patients with a history of bronchospasm.

Patients with a history of hypersensitivity to any of the components of Aero-Vent.

Salbutamol 2.5-mg nebules should be used with care in patients known to have received large doses of other sympathomimetic drugs. It should be administered cautiously to patients suffering from thyrotoxicosis.
Great care is also needed in patients with cardiovascular disease eg, ischemic heart disease, arrhythmia or tachycardia, hypertension.
Care is also required when sympathomimetic agents are given to patients with diabetes mellitus or closed-angle glaucoma.
An increased risk of arrhythmias may also occur if sympathomimetic agents are given to patients receiving cardiac glycosides, quinidine or tricyclic antidepressants.
As with other inhalation therapy, the potential for paradoxical bronchospasm should be kept in mind. If it occurs, the preparation should be discontinued immediately and alternative therapy instituted.
Patients receiving treatment at home with salbutamol 2.5-mg nebules should seek medical advice if either the usual relief is diminished or the usual duration of action reduced. Patients should not increase the dose or the frequency of administration of salbutamol.
Use in pregnancy: Unnecessary administration of drugs during the 1st trimester of pregnancy is undesirable.

A small increase in heart rate may occur in patients who inhale a large dosage of salbutamol. This is not usually accompanied by any changes in the electrocardiogram. Other side effects which occur with very high doses of salbutamol by inhalation are peripheral vasodilatation and the fine tremor of skeletal muscle.

Store nebules in the box at temperatures not exceeding 25°C. Protect from light.
Shelf-Life: 36 months.

Antiasthmatic & COPD Preparations

R03AC02 - salbutamol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.

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