Anxiol Dosage/Direction for Use

Diazepam administered parenterally with the risk of dependence very much influencing the dose and duration of treatment. Doses should be the lowest that can control symptoms and courses of treatment should be short, not normally exceeding 4 weeks, with diazepam being withdrawn gradually. Elderly and debilitated patients should be given not more than one-half the usual adult dose. Dosage reduction may also be required in patients with liver or kidney dysfunction.
Diazepam is also given by deep intramuscular or slow intravenous injection. Although absorption following intramuscular injection may be erratic and provides lower blood concentrations than those following oral administration. Intravenous injection should be carried out slowly into a large vein of the antecubital fossa at a recommended rate of no more than 1 mL of a 0.5% solution (5 mg) per minute. It is advisable to keep the patient in the supine position and under medical supervision for at least an hour after administration. Diazepam may be administered by continuous intravenous infusion; because of the risk of precipitation of diazepam, solutions should be freshly prepared. Facilities for resuscitation should always be available when diazepam is given intravenously.
Diazepam may be given for severe anxiety by intramuscular or intravenous injection when a dose of up to 10 mg may be given, repeatedly if necessary after 4 hours.
Diazepam given for premedication before general anesthesia by intravenous injection the dose is usually 100 to 200 mcg per kg body-weight. Diazepam may also be given for sedation during minor surgical and medical procedures; doses of 10 to 20 mg, given by intravenous injection over 2 to 4 minutes are recommended.
Diazepam is used in a variety of seizures. It is given intravenously to adults in a dose of 10 to 20 mg given at a rate of 5 mg per minute and repeated if necessary after 30 to 60 minutes. Other schedules involve administering smaller amounts more frequently or giving diazepam, intramuscularly, though again absorption may be slow. Once the seizures have been controlled, a slow intravenous infusion providing up to 3 mg per kg over 24 hours has been administered to protect against recurrence. Doses by intravenous or intramuscular injection in children are within the range of 200 to 300 mcg per kg; alternatively 1 mg may be given for each year of age.
Diazepam may be given to alleviate muscles spasm. If given by intramuscular or slow intravenous injection the dose is 10 mg repeated if necessary after 4 hours. Larger doses are used in tetanus in adults and children with 100 to 300 mcg per kg body-weight being given every 1 to 4 hours by intravenous injection. Alternatively 3 to 10 mg per kg may be given over 24 hours by continuous intravenous infusion.
Symptoms of the alcohol withdrawal syndrome may be controlled by diazepam. It is given by injection if the symptoms are severe and if delirium tremens has developed; 10 to 20 mg by intramuscular or intravenous injection may be adequate, although some patients may require higher doses.
Or as prescribed by a physician.