Anzenil Adverse Reactions

The adverse effects experienced during use of flumazenil are generally due to the reversal of benzodiazepine effects and resemble benzodiazepine withdrawal symptoms. Nausea, vomiting, dizziness, blurred vision, headache, and flushing may occur. Anxiety, fear, and agitation have been reported after too rapid reversal of sedation. There have been reports of seizures, especially in epileptics. Transient increases in blood pressure and heart rate have been observed. Hypersensitivity reactions have occurred rarely. Patients who have received benzodiazepines for prolonged periods are particularly at risk of experiencing withdrawal symptoms and rapid injection of flumazenil should be avoided in such patients. Because of its short duration of action, patients given flumazenil to reverse benzodiazepine-induced sedation should be kept under close observation; further doses of flumazenil may be necessary.