Sign Out
Signs and symptoms: In clinical trials and post-marketing experience, accidental or intentional acute overdose of aripiprazole was identified in adult patients with reported estimated doses up to 1,260 mg with no fatalities.
The potential medically important signs and symptoms observed included lethargy, increased blood pressure, somnolence, tachycardia, nausea, vomiting and diarrhoea. In addition, reports of occidental overdose with aripiprazole alone (up to 195 mg) in children have been received with no fatalities. The potentially medically serious signs and symptoms reported included somnolence, transient loss of consciousness and extrapyramidal symptoms.
Management of overdose: Management of overdose should concentrate and supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and management of symptoms.
The possibility of multiple medicinal product involvement should be considered. Therefore cardiovascular monitoring should be started immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias.
Following any confirmed or suspected overdose with aripiprazole, close medical supervision and monitoring should continue until the patient recovers.
Activated charcoal (50 g), administrated one hour after aripiprazole, decreased aripiprazole Cmax by about 41% and AUC by about 51%; suggesting that charcoal may be effective in the treatment of overdose.
Haemodialysis: Although there is no information on the effect of haemodialysis in treating an overdose with aripiprazole, haemodialysis is unlikely to be useful in overdose management Since aripiprazole is highly bound to plasma proteins.
