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Desloratadine taken concomitantly with alcohol does not potentiate the performance impairing effects of alcohol.
Co-administration of Desloratadine with ketoconazole increases the maximum Desloratadine concentration (Cmax) by 45% and the area under the time concentration curve (AUC) by 37%.
Co-administration of Desloratadine with erythromycin increased the Cmax of Desloratadine by 24% and the AUC by 14%. The increase of Cmax and AUC of Desloratadine when co-adminstered with either ketoconazole or erythromycin did not cause any clinical relevant adverse events in the populations studied.
