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Pharmacology: Pharmacodynamics & Pharmacokinetics: Salbutamol is a selective Beta-2 adrenoceptor agonist. At therapeutic doses, it acts on the Beta-2 adrenoceptor of bronchial muscle with little or no action on the Beta-1 adrenoceptor of cardiac muscle.
Guaifenesin can make the viscous mucus of the respiratory pathways more fluid and therefore facilitates expectoration and reduces cough.
In the presence of excessive mucus, adequate pulmonary ventilation cannot be achieved simply by relieving bronchospasm. It is necessary to remove mucus obstruction. The combination of salbutamol and guaifenesin is designed to relieve respiratory obstruction and improve pulmonary ventilation.
