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Based on in vitro data, azacitidine metabolism does not appear to be mediated by cytochrome P450 isoenzymes (CYPs), UDP-glucuronosyltransferases (UGTs), sulfotransferases (SULTs), and glutathione transferases (GSTs); interactions related to these metabolizing enzymes in vivo are therefore considered unlikely.
Clinically significant inhibitory or inductive effects of azacitidine on cytochrome P450 enzymes are unlikely.
No formal clinical drug interaction studies with azacitidine have been conducted.
