Resp tract (including otitis media), skin & soft-tissue, & uncomplicated genital infections. Prophylaxis & as a component of regimens in the treatment of Mycobacterium avium complex (MAC). Prophylaxis of endocarditis in at-risks patients unable to take penicillin. Management of trachoma & typhoid.
Adult Usual dose: 500 mg as a single daily dose for 3 days. Initial dose: 500 mg, followed by 250 mg daily for 4 days. Uncomplicated genital infections due to Chlamydia trachomatis 1 g as a single dose. Uncomplicated gonorrhea 2 g as a single dose. Prophylaxis of disseminated MAC infections 1.2 g once wkly.
GI disturbances. Headache, somnolence, & taste disturbances. Agranulocytosis, aggravation of muscular weakness in myasthenia gravis patients, & pancreatitis; prolongation of QT interval & other arrhythmias, including torsades de pointes.
Reduced rate of absorption w/ antacids containing Al or Mg salts. Theoretical possibility of risk of ergotism w/ ergot derivatives. Impair metabolism of digoxin (in the gut). Increased rifabutin toxicity.
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